A. Research notes, 1931-2009, 1931-2009
Scope and Contents
Consists of materials relating to Paul C. Zamecnik's career as a research scientist. This includes reference files from his time as a student, as well as research summaries, raw and analyzed research data, laboratory notebooks, research protocols and experiment procedures, and more general notes relating to laboratory research at Harvard Medical School, the Collis P. Huntington Memorial Hospital, Massachusetts General Hospital, the Worcester Foundation for Experimental Biology, Hybridon, Inc., ZATA Pharmaceuticals, Inc., and Cold Spring Harbor Laboratory. Records include raw and analyzed data; experiment procedures; research summaries; charts and images; laboratory notebooks and more general notes regarding data; and occasional related scientific journal reprints and correspondence. The research data covers topics related to Zamecnik's interests in biochemistry and gene repair over the course of his eighty-year career, including antisense oligonucleotides and their role in therapeutic gene repair, diadenosine tetraphosphate, protein synthesis, RNA and ribosomal structures, tRNA, microRNA, ribonucleotides, chloroplasts, Hodgkin's disease, Rous sarcoma virus replication and transformation, UV radiation and cancer, plaque assays, inhibition, gradients, melanin, malaria, Leishmania, prostate cancer, celiac disease, cell storage, ATP, and DNA modification, among others.
Dates
- Creation: 1931-2009
Language of Materials
Papers are predominantly in English. Some papers are in Dutch, French, German, and Russian.
Conditions Governing Access
Subseries A includes files with personally-identifying information that is restricted for 80 years from the date of record creation, and Harvard University records that are restricted for 50 years. The end of the restricted period is noted with each folder.
Extent
28.2 cubic feet (26 records center cartons, 2 letter size document boxes, 4 oversized boxes)Arrangement
Subseries A is arranged in three sub-subseries: 1. Antisense oligonucleotides and diadenosine tetraphosphate notes, 1936-2009; 2. RNA and tRNA notes, 1953-2001; and 3. Other research notes, 1934-2009.
Creator
- From the Collection: Zamecnik, Paul Charles, 1912-2009 (Person)
Repository Details
Part of the Center for the History of Medicine (Francis A. Countway Library of Medicine) Repository
The Center for the History of Medicine in the Francis A. Countway Library of Medicine is one of the world's leading resources for the study of the history of health and medicine. Our mission is to enable the history of medicine and public health to inform healthcare, the health sciences, and the societies in which they are embedded.