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The Benjamin Waterhouse papers, 1797-1829 (inclusive), consist of Waterhouse's (1754-1846) letters to colleagues, including Lyman Spalding (1775-1821), concerning smallpox inoculation and other medical topics. There are also copies of manuscript letters to the Harvard Corporation in which Waterhouse defends himself against allegations he was working against the interests of Harvard Medical School.
The Jacob Bigelow papers, 1770-1879 (inclusive), 1800-1879 (bulk), contain correspondence with Jacob Bigelow's (1786-1879) colleagues concerning botanical specimens, publication of the Pharmacopoeia of the United States from 1820 to 1831, and general medical matters. There is also correspondence with his family, including his parents, siblings, and his son, physician Henry Jacob Bigelow (1818-1890).